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The characters in an Odd Friendship may have little to do with each other initially — or even begin as bitter enemies — and their friendship grows over time.Distinguished from an Odd Couple in that these are usually two characters in an ensemble show, or a regular character and a Recurrer; whereas an Odd Couple usually consists of the two main characters in a show.If one is not available, advice can be obtained from a poison control center.First aid recommendations should be intended for first responders and include specific treatment only when there is an antidote or intervention generally accepted as effective, and early administration could substantially improve outcome.A friendship which develops between two characters that would seem unlikely to be friends, whether it's because of them having diametrically opposed personalities, holding beliefs that would normally get one to try to demonize the other, or some other quirks of their beings that would lead to them clashing.Through their friendship, they learn more about each other and about themselves.
Even when the specific drugs are quantitatively identified, the use of kinetic data to determine clinical effects is limited because drugs often have prolonged half-lives in overdose.
In addition, the pharmacokinetics of many drugs will be altered in patients with organ failure [12, 13].
Furthermore, the pharmacokinetics of absorption and elimination of a drug in large dose may be different than published pharmacokinetic data suggest, which are typically obtained following therapeutic dosing, generally in healthy subjects without co-exposures .
References The position of the American College of Medical Toxicology, endorsed by the American Academy of Clinical Toxicology and the Society of Critical Care Medicine, is as follows: We agree with the American Academy of Neurology (AAN) recommendation that the clinical determination of brain death should only be made in the absence of drug intoxication or poisoning.
However, a drug screen and clearance calculation using five drug half-lives (T1/2) are not sufficient to exclude intoxication in all cases.